Mostrar el registro sencillo del ítem

Anticonvulsant and Antioxidant Effects of Tilia americana var. mexicana and Flavonoids Constituents in the Pentylenetetrazole-Induced Seizures

dc.creatorCardenas-Rodriguez, N.
dc.creatorGonzalez-Trujano, M. E.
dc.creatorAguirre-Hernandez, E.
dc.creatorRuiz-Garcia, M.
dc.creatorSampieri, A.
dc.creatorCoballase-Urrutia, E.
dc.creatorCarmona-Aparicio, L.
dc.date.accessioned2017-06-29T03:41:32Z
dc.date.available2017-06-29T03:41:32Z
dc.date.issued2014es_ES
dc.identifier2540es_ES
dc.identifier.issn1942-0900 es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4389
dc.identifier.urihttps://doi.org/10.1155/2014/329172es_ES
dc.language.isoenges_ES
dc.relation329172 1-10p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAnticonvulsant and Antioxidant Effects of Tilia americana var. mexicana and Flavonoids Constituents in the Pentylenetetrazole-Induced Seizureses_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratory of Neurochemistry, National Institute of Pediatrics, 04530 Mexico City, DF, Mexicoes_ES
dc.contributor.emailelcoballase@yahoo.com.mxes_ES
dc.relation.jnabreviadoOXIDA MED CELL LONGes_ES
dc.relation.journalOxidative Medicine and Cellular Longevityes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1942-0994es_ES
dc.identifier.doi10.1155/2014/329172es_ES
dc.description.abstractotrodiomaTilia genus is commonly used around the world for its central nervous system properties; it is prepared as tea and used as tranquilizing, anticonvulsant, and analgesic. In this study, anticonvulsant activity of the Tilia americana var. mexicana inflorescences and leaves was investigated by evaluating organic and aqueous extracts (100, 300, and 600 mg/kg, i.p.) and some flavonoids in the pentylenetetrazole-induced seizures in mice. Moreover, antioxidant effect of these extracts and flavonoids was examined in an in vitro study by using spectrophotometric technique. Significant activity was observed in the methanol extract from inflorescences. An HPLC analysis of the methanol extract from inflorescences and leaves of Tilia allowed demonstrating the respective presence of some partial responsible flavonoid constituents: quercetin (20.09 +/- 1.20 mu g/mg and 3.39 +/- 0.10 mu g/mg), rutin (3.52 +/- 0.21 mu g/mg and 8.94 +/- 0.45 mu g/mg), and isoquercitrin (1.74 +/- 0.01 mu g/mg and 1.24 +/- 0.13 mu g/mg). In addition, significant but different antioxidant properties were obtained among the flavonoids and the extracts investigated. Our results provide evidence of the anticonvulsant activity of Tilia reinforcing its utility for central nervous system diseases whose mechanism of action might involve partial antioxidant effects due to the presence of flavonoids.es_ES
dc.subject.koBenzodiazepine-Receptor Ligandses_ES
dc.subject.koLipid-Peroxidationes_ES
dc.subject.koSinglet Oxygenes_ES
dc.subject.koAlzheimers-Diseasees_ES
dc.subject.koHypochlorous Acides_ES
dc.subject.koMicees_ES
dc.subject.koInflorescenceses_ES
dc.subject.koMechanismses_ES
dc.subject.koChemistryes_ES
dc.subject.koAnxietyes_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem