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Age differences in the impact of forced swimming test on serotonin transporter levels in lateral septum and dorsal raphe

dc.creatorUlloa, Rosa-Elena
dc.creatorDiaz-Valderrama, Aliyeri
dc.creatorHerrera-Perez, Jaime
dc.creatorLeon-Olea, Martha
dc.creatorMartinez-Mota, Lucia
dc.date.accessioned2017-06-29T03:41:10Z
dc.date.available2017-06-29T03:41:10Z
dc.date.issued2014es_ES
dc.identifier2521es_ES
dc.identifier.issn1744-9081 es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4370
dc.identifier.urihttps://doi.org/10.1186/1744-9081-10-3es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisheres_ES
dc.relation10(3) 1-8p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAge Factorses_ES
dc.subject.meshAnimalses_ES
dc.subject.meshBehavior, Animal/physiologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshRaphe Nuclei/metabolismes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshSeptal Nuclei/metabolismes_ES
dc.subject.meshSerotonin Plasma Membrane Transport Proteins/metabolismes_ES
dc.subject.meshStress, Physiological/physiologyes_ES
dc.subject.meshStress, Psychological/metabolismes_ES
dc.subject.meshSwimminges_ES
dc.titleAge differences in the impact of forced swimming test on serotonin transporter levels in lateral septum and dorsal raphees_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.contributor.emaillucia@imp.edu.mxes_ES
dc.relation.jnabreviadoBEHAV BRAIN FUNCTes_ES
dc.relation.journalBehavioral and Brain Functionses_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissnes_ES
dc.identifier.doi10.1186/1744-9081-10-3es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaBACKGROUND:  Forced swimming test (FST) is an animal model which evaluates behavioral despair and the effect of antidepressants such as the selective serotonin reuptake inhibitors; the FST modifies the expression of some receptors related to antidepressant response, but it is not known whether serotonin transporter (SERT), their main target, is affected by this test in animals of different ages. Antidepressant response has shown age-dependent variations which could be associated with SERT expression. The aim of the present study was to analyze changes in the SERT immunoreactivity (SERT-IR) in dorsal raphe and lateral septum of male rats from different age groups with or without behavioral despair induced by their exposure to the FST, since these two structures are related to the expression of this behavior. METHODS:  Prepubertal (24 PN), pubertal (40 PN), young adult (3-5 months) and middle-aged (12 months) male rats were assigned to a control group (non-FST) or depressed group (FST, two sessions separated by 24 h). Changes in SERT-IR in dorsal raphe and lateral septum were determined with immunofluorescence. RESULTS:  Pubertal and middle-aged rats showed higher levels of immobility behavior compared to prepubertal rats on the FST. SERT-IR showed an age-dependent increase followed by a moderate decrease in middle-aged rats in both structures; a decreased in SERT-IR in lateral septum and dorsal raphe of pubertal rats was observed after the FST. CONCLUSIONS:  Age differences were observed in the SERT-IR of structures related to behavioral despair; SERT expression was modified by the FST in lateral septum and dorsal raphe of pubertal rats.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koEpidemiologyes_ES
dc.subject.koDepressiones_ES
dc.subject.koAnxietyes_ES
dc.subject.koAnxiety Disorderses_ES
dc.subject.koSuicidees_ES
dc.subject.koSelf-Harmes_ES
dc.subject.koPanic Attackses_ES
dc.subject.koDespaires_ES
dc.subject.koForced swimming testes_ES
dc.subject.koRatses_ES
dc.subject.koSerotonin transporteres_ES
dc.subject.koAge differenceses_ES


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