Mostrar el registro sencillo del ítem

A Novel Role for Endogenous Pituitary Adenylate Cyclase Activating Polypeptide in the Magnocellular Neuroendocrine System

dc.creatorGillard, ER
dc.creatorLeón-Olea, M
dc.creatorMucio-Ramírez, S
dc.creatorCoburn, CG
dc.creatorSánchez-Islas, E
dc.creatorDe Leon, A
dc.creatorMussenden, H
dc.creatorBauce, LG
dc.creatorPittman, QJ
dc.creatorCurrás-Collazo, MC
dc.date.accessioned2017-06-29T03:40:59Z
dc.date.available2017-06-29T03:40:59Z
dc.date.issued2006es_ES
dc.identifier2510es_ES
dc.identifier.issn0013-7227es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4359
dc.identifier.urihttps://doi.org/10.1210/en.2005-1103es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisheres_ES
dc.relation147(2) 791-803p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdaptation, Physiologicales_ES
dc.subject.meshAnimalses_ES
dc.subject.meshDehydration/metabolismes_ES
dc.subject.meshImmunohistochemistryes_ES
dc.subject.meshMalees_ES
dc.subject.meshNeurosecretory Systems/cytologyes_ES
dc.subject.meshNeurosecretory Systems/metabolismes_ES
dc.subject.meshPituitary Adenylate Cyclase-Activating Polypeptide/metabolismes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Sprague-Dawleyes_ES
dc.subject.meshReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I/metabolismes_ES
dc.subject.meshSignal Transduction/physiologyes_ES
dc.subject.meshSupraoptic Nucleus/cytologyes_ES
dc.subject.meshSupraoptic Nucleus/metabolismes_ES
dc.subject.meshVasopressins/secretiones_ES
dc.subject.meshWater-Electrolyte Balance/physiologyes_ES
dc.titleA Novel Role for Endogenous Pituitary Adenylate Cyclase Activating Polypeptide in the Magnocellular Neuroendocrine Systemes_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartment of Cell Biology and Neuroscience (E.R.G., A.d.L., H.M., M.C.C.-C.) and Environmental Toxicology Program (C.G.C.), University of California at Riverside, Riverside, California 92521es_ES
dc.contributor.emailes_ES
dc.relation.jnabreviadoENDOCRINOLOGYes_ES
dc.relation.journalEndocrinologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1945-7170es_ES
dc.identifier.doi10.1210/en.2005-1103es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaCentral release of vasopressin (VP) by the magnocellular neuroendocrine cells (MNCs) responsible for systemic VP release is believed to be important in modulating the activity of these neurons during dehydration. Central VP release from MNC somata and dendrites is stimulated by both dehydration and pituitary adenylate cyclase activating polypeptide (PACAP). Although PACAP is expressed in MNCs, its potential role in the magnocellular response to dehydration is unexplored. The current study demonstrates that prolonged dehydration increases immunoreactivity for PACAP-27, PACAP-38, and the type I PACAP receptor in the supraoptic nucleus (SON) of the rat. In addition, PACAP stimulates local VP release in the euhydrated rat SON in vitro, and this effect is reduced by the PACAP receptor antagonist PAC(6-27) (100 nm), suggesting the participation of PACAP receptors. Concomitant with its effects on local VP release, PACAP also reduces basal glutamate and aspartate release in the euhydrated rat SON. Furthermore, somatodendritic VP release elicited by acute dehydration is blocked by PAC(6-27), suggesting that endogenous PACAP participates in this response. Consistent with this, RIA revealed that local PACAP-38 release within the SON is significantly elevated during acute dehydration. These results suggest that prolonged activation of hypothalamic MNCs is accompanied by up-regulation of PACAP and the type I PACAP receptor in these cells and that somatodendritic VP release in response to acute dehydration is mediated by activation of PACAP receptors by endogenous PACAP released within the SON. A potential role for PACAP in promoting efficient, but not exhaustive, systemic release of VP from MNCs during physiological challenge is discussed.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koes_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem