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A D2-like receptor family agonist produces analgesia in mechanonociception but not in thermonociception at the spinal cord level in rats

dc.creatorAlmanza, Angélica
dc.creatorSimón-Arceo, Karina
dc.creatorCoffeen, Ulises
dc.creatorFuentes-García, Ruth
dc.creatorContreras, Bernardo
dc.creatorPellicer, Francisco
dc.creatorMercado, Francisco
dc.date.accessioned2017-06-29T03:40:56Z
dc.date.available2017-06-29T03:40:56Z
dc.date.issued2015es_ES
dc.identifier2507es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/j.pbb.2015.08.013     es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4356
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0091305715300502es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisheres_ES
dc.relation137 119-125p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnalgesia-Methodses_ES
dc.subject.meshAnimalses_ES
dc.subject.meshDopamine agonists-Administration and dosagees_ES
dc.subject.meshHot temperature-Adverse effectses_ES
dc.subject.meshInjections, Spinales_ES
dc.subject.meshMalees_ES
dc.subject.meshPain-Drug therapyes_ES
dc.subject.meshPain-Metabolismes_ES
dc.subject.meshPhysical stimulation-Adverse effectses_ES
dc.subject.meshQuinpirole-Administration and dosagees_ES
dc.subject.meshRatses_ES
dc.subject.meshReceptors, Dopamine D2-Agonistses_ES
dc.subject.meshReceptors, Dopamine D2-Metabolismes_ES
dc.subject.meshSpinal Cord-Drug effectses_ES
dc.subject.meshSpinal Cord-Metabolismes_ES
dc.titleA D2-like receptor family agonist produces analgesia in mechanonociception but not in thermonociception at the spinal cord level in ratses_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratorio de Fisiología Celular, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Del. Tlalpan, C.P. 14370 México D.F., Méxicoes_ES
dc.contributor.emailpellicer@imp.edu.mx, fmercado@imp.edu.mx, mercado.aca@gmail.comes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2015es_ES
dc.identifier.organizaciones_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/j.pbb.2015.08.013es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaThe administration of dopaminergic drugs produces analgesia in individuals experiencing different types of pain. Analgesia induced by these drugs at the spinal cord level is mediated by D2-like agonists, which specifically inhibit the detection of nociceptive stimuli by sensory afferents. The extent of the analgesia provided by spinal dopamine agonists remains controversial, and the cellular mechanism of this analgesic process is poorly understood. The objective of this study was to evaluate the analgesic effect of quinpirole, a D2-like agonist, based on two nociceptive tests and at various doses that were selected to specifically activate dopamine receptors. We found that intrathecal quinpirole administration produces analgesia of mechanical but not thermal nociception and that the analgesic effect of quinpirole is reversed by a mix of D2, D3, and D4 receptor-specific antagonists, suggesting that the activation of all D2-like receptors is involved in the analgesia produced by intrathecal quinpirole. The differential effect on thermal and mechanical nociception was also tested upon the activation of μ-opioid receptors. As reported previously, low doses of the μ-opioid receptor agonist DAMGO produced analgesia of only thermonociception. This evidence shows that a D2-like receptor agonist administered at the spinal cord level produces analgesia specific to mechanonociception but not thermonociceptiones_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koMechanonociceptiones_ES
dc.subject.koThermonociceptiones_ES
dc.subject.koD2-like dopamine receptores_ES
dc.subject.koModulationes_ES
dc.subject.koAnalgesiaes_ES


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