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Mostrando ítems 31-40 de 43
Efecto de la melatonina sobre la actividad de la proteína cinasa C y la distribución de filamentos intermedios en las células N1E-115
(1995)
En los años recientes hemos demostrado que uno de los mecanismos de acción de la melatonina (MEL), ocurre a nivel intracelular. La hormona se une a la calmodulina con alta afinidad (188 pM) en presencia de calcio y antagoniza ...
Neurocytoskeletal Protective Effect of Melatonin: Importance for Morphofunctional Neuronal Polarization
(2010)
Neurons have a highly asymmetric shape and they are constituted by two functional domains: the axonal, and the somatodendritic domains. Axons are cellular processes that make contact with target cells to transmit information, ...
In Vitro Stimulation of Protein Kinase C by Melatonin
(1998)
It has been shown that melatonin through binding to calmodulin acts both in vitro and in vivo as a potent calmodulin antagonist. It is known that calmodulin antagonists both bind to the hydrophobic domain of Ca2+ activated ...
ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration
(2009)
Cell movement is generated by a driving force provided by dynamic cytoskeletal organization. Two main cytoskeletal-dependent features, essential for migration, are the highly cell polarized structure and focal adhesion ...
Melatonin Modulates Cell Survival of New Neurons in the Hippocampus of Adult Mice
(2009)
Regulation of adult hippocampal neurogenesis is influenced by circadian rhythm, affected by the manipulation of sleep, and is disturbed in animal models of affective disorders. These observations and the link between ...